diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
index da9a359..e7b6ce0 100644
--- a/entries/interactome_stelzl/__init__.py
+++ b/entries/interactome_stelzl/__init__.py
@@ -18,32 +18,69 @@
 
 from .. import *
 
-title = "Stelzl human interactome (2005)"
-description = """A network of human proteins and their binding interactions. Nodes represent proteins and an edge represents an interaction between two proteins, as inferred via high-throughput Y2H experiments using bait and prey methodology.[^icon]
-[^icon]: Description obtained from the [ICON](https://icon.colorado.edu) project."""
-tags = ['Biological', 'Protein interactions', 'Unweighted']
-url = 'http://konect.cc/networks/maayan-Stelzl'
-citation = [('U. Stelzl et al. "A human protein-protein interaction network: a resource for annotating the proteome." Cell 122, 957-968 (2005)', 'https://doi.org/10.1016/j.cell.2005.08.029')]
+title = 'Stelzl human interactome (2005)'
+description = """A network of interactions between human proteins, from a systematic yeast two-hybrid (Y2H) screen by Stelzl et al. (2005), in which a matrix of 4,456 bait and 5,632 prey proteins was tested by automated interaction mating, identifying 3,186 mostly novel interactions among 1,705 proteins. The data were obtained from the network collection of the Ma'ayan Laboratory (Mount Sinai School of Medicine), which distributed them in its SIG flat file format, with proteins identified by gene symbols and, where available, UniProt accessions. All interactions are of type "Binding".
+
+Nodes are proteins, and edges are directed, following the order of the two proteins in the source file; the meaning of the direction is not documented. Most interactions are listed in both directions (3,016 pairs of proteins are connected both ways), so that the 6,207 directed edges correspond to 3,191 unordered pairs. Self-loops denote proteins that interact with themselves.
+
+The network has the following properties:
+
+- Nodes: `name`, the gene symbol of the protein; `uniprot_human` and `uniprot_mouse`, the UniProt accessions of the human protein and of its mouse orthologue (empty if not available)."""
+tags = ['Biological', 'Protein interactions', 'Unweighted', 'Metadata']
+url = 'https://web.archive.org/web/20180916202441/http://research.mssm.edu/maayan/datasets/qualitative_networks.shtml'
+citation = [('U. Stelzl et al., "A human protein-protein interaction network: a resource for annotating the proteome." Cell 122(6), 957-968 (2005)', 'https://doi.org/10.1016/j.cell.2005.08.029')]
 icon_hash = '58065a248cf714f319c3be90'
-upstream_prefix = 'http://konect.cc/files'
-files = [('download.tsv.maayan-Stelzl.tar.bz2', None, 'konect')]
+upstream_license = None
+# The Ma'ayan Laboratory site is gone; the file is obtained from the Internet
+# Archive.
+upstream_prefix = 'https://web.archive.org/web/20150912005125id_/http://research.mssm.edu:80/maayan/datasets'
+files = [('Stelzl.sig', None, 'sig')]
 
 def fetch_upstream(force=False):
     return fetch_upstream_files(__name__.split(".")[-1], upstream_prefix, files,
                                 force)
 
+def read_sig(f):
+    """Read a SIG file of the Ma'ayan Laboratory: one interaction per line, with
+    13 space-separated columns (source name, human and mouse accessions, type
+    and location; the same for the target; effect, interaction type, PubMed
+    IDs), "NA" denoting missing values."""
+    for line in f.read().decode("utf-8").splitlines():
+        line = line.split()
+        if len(line) == 0:
+            continue
+        yield [None if x == "NA" else x for x in line]
+
 @cache_network()
 @coerce_props()
 @annotate()
 def parse(alts=None):
     global files
     name = __name__.split(".")[-1]
-    for fnames, alt, fmt in files:
+    for fname, alt, fmt in files:
         if alts is not None and alt not in alts:
             continue
-        if isinstance(fnames, str):
-            fnames = [fnames]
-        with ExitStack() as stack:
-            fs = [stack.enter_context(open_upstream_file(name, fn, "rb")) for fn in fnames]
-            g = parse_graph(fs, fmt, directed=True)
+        g = Graph(directed=True)
+        vs = {}
+        acc = defaultdict(lambda: [None, None])
+        edges = []
+        with open_upstream_file(name, fname, "rb") as f:
+            for row in read_sig(f):
+                ends = []
+                for i in (0, 5):
+                    v = vs.setdefault(row[i], len(vs))
+                    ends.append(v)
+                    for j in (0, 1):
+                        if row[i + 1 + j] is not None:
+                            acc[v][j] = row[i + 1 + j]
+                edges.append(ends)
+        g.add_vertex(len(vs))
+        g.vp.name = g.new_vp("string")
+        g.vp.uniprot_human = g.new_vp("string")
+        g.vp.uniprot_mouse = g.new_vp("string")
+        for k, v in vs.items():
+            g.vp.name[v] = k
+            g.vp.uniprot_human[v] = acc[v][0] or ""
+            g.vp.uniprot_mouse[v] = acc[v][1] or ""
+        g.add_edge_list(edges)
         yield alt, g

diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
index ba0a6b3..da9a359 100644
--- a/entries/interactome_stelzl/__init__.py
+++ b/entries/interactome_stelzl/__init__.py
@@ -1,7 +1,7 @@
 #! /usr/bin/env python
 # -*- coding: utf-8 -*-
 #
-# Copyright (C) 2020-2024 Tiago de Paula Peixoto <tiago@skewed.de>
+# Copyright (C) 2020-2026 Tiago de Paula Peixoto <tiago@skewed.de>
 #
 # This program is free software: you can redistribute it and/or modify it under
 # the terms of the GNU Affero General Public License as published by the Free

diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
index 7586ae0..ba0a6b3 100644
--- a/entries/interactome_stelzl/__init__.py
+++ b/entries/interactome_stelzl/__init__.py
@@ -1,7 +1,7 @@
 #! /usr/bin/env python
 # -*- coding: utf-8 -*-
 #
-# Copyright (C) 2020-2023 Tiago de Paula Peixoto <tiago@skewed.de>
+# Copyright (C) 2020-2024 Tiago de Paula Peixoto <tiago@skewed.de>
 #
 # This program is free software: you can redistribute it and/or modify it under
 # the terms of the GNU Affero General Public License as published by the Free

diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
index 2b540e5..7586ae0 100644
--- a/entries/interactome_stelzl/__init__.py
+++ b/entries/interactome_stelzl/__init__.py
@@ -1,7 +1,7 @@
 #! /usr/bin/env python
 # -*- coding: utf-8 -*-
 #
-# Copyright (C) 2021 Tiago de Paula Peixoto <tiago@skewed.de>
+# Copyright (C) 2020-2023 Tiago de Paula Peixoto <tiago@skewed.de>
 #
 # This program is free software: you can redistribute it and/or modify it under
 # the terms of the GNU Affero General Public License as published by the Free

diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
index e68965b..2b540e5 100644
--- a/entries/interactome_stelzl/__init__.py
+++ b/entries/interactome_stelzl/__init__.py
@@ -1,7 +1,7 @@
 #! /usr/bin/env python
 # -*- coding: utf-8 -*-
 #
-# Copyright (C) 2020 Tiago de Paula Peixoto <tiago@skewed.de>
+# Copyright (C) 2021 Tiago de Paula Peixoto <tiago@skewed.de>
 #
 # This program is free software: you can redistribute it and/or modify it under
 # the terms of the GNU Affero General Public License as published by the Free

diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
index 6820860..e68965b 100644
--- a/entries/interactome_stelzl/__init__.py
+++ b/entries/interactome_stelzl/__init__.py
@@ -26,7 +26,6 @@ url = 'http://konect.cc/networks/maayan-Stelzl'
 citation = [('U. Stelzl et al. "A human protein-protein interaction network: a resource for annotating the proteome." Cell 122, 957-968 (2005)', 'https://doi.org/10.1016/j.cell.2005.08.029')]
 icon_hash = '58065a248cf714f319c3be90'
 upstream_prefix = 'http://konect.cc/files'
-orphan = True
 files = [('download.tsv.maayan-Stelzl.tar.bz2', None, 'konect')]
 
 def fetch_upstream(force=False):

diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
index b6617d2..6820860 100644
--- a/entries/interactome_stelzl/__init__.py
+++ b/entries/interactome_stelzl/__init__.py
@@ -23,7 +23,7 @@ description = """A network of human proteins and their binding interactions. Nod
 [^icon]: Description obtained from the [ICON](https://icon.colorado.edu) project."""
 tags = ['Biological', 'Protein interactions', 'Unweighted']
 url = 'http://konect.cc/networks/maayan-Stelzl'
-citation = [('U. Stelzl et al. "A human protein-protein interaction network: a resource for annotating the proteome." Cell 122, 957-968 (2005)', 'http://www.sciencedirect.com/science/article/pii/S0092867405008664')]
+citation = [('U. Stelzl et al. "A human protein-protein interaction network: a resource for annotating the proteome." Cell 122, 957-968 (2005)', 'https://doi.org/10.1016/j.cell.2005.08.029')]
 icon_hash = '58065a248cf714f319c3be90'
 upstream_prefix = 'http://konect.cc/files'
 orphan = True

diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
index 97a0cb1..b6617d2 100644
--- a/entries/interactome_stelzl/__init__.py
+++ b/entries/interactome_stelzl/__init__.py
@@ -26,6 +26,7 @@ url = 'http://konect.cc/networks/maayan-Stelzl'
 citation = [('U. Stelzl et al. "A human protein-protein interaction network: a resource for annotating the proteome." Cell 122, 957-968 (2005)', 'http://www.sciencedirect.com/science/article/pii/S0092867405008664')]
 icon_hash = '58065a248cf714f319c3be90'
 upstream_prefix = 'http://konect.cc/files'
+orphan = True
 files = [('download.tsv.maayan-Stelzl.tar.bz2', None, 'konect')]
 
 def fetch_upstream(force=False):

diff --git a/entries/interactome_stelzl/__init__.py b/entries/interactome_stelzl/__init__.py
new file mode 100644
index 0000000..97a0cb1
--- /dev/null
+++ b/entries/interactome_stelzl/__init__.py
@@ -0,0 +1,49 @@
+#! /usr/bin/env python
+# -*- coding: utf-8 -*-
+#
+# Copyright (C) 2020 Tiago de Paula Peixoto <tiago@skewed.de>
+#
+# This program is free software: you can redistribute it and/or modify it under
+# the terms of the GNU Affero General Public License as published by the Free
+# Software Foundation, either version 3 of the License, or (at your option) any
+# later version.
+#
+# This program is distributed in the hope that it will be useful, but WITHOUT
+# ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+# FOR A PARTICULAR PURPOSE.  See the GNU Affero General Public License for more
+# details.
+#
+# You should have received a copy of the GNU Affero General Public License along
+# with this program.  If not, see <http://www.gnu.org/licenses/>.
+
+from .. import *
+
+title = "Stelzl human interactome (2005)"
+description = """A network of human proteins and their binding interactions. Nodes represent proteins and an edge represents an interaction between two proteins, as inferred via high-throughput Y2H experiments using bait and prey methodology.[^icon]
+[^icon]: Description obtained from the [ICON](https://icon.colorado.edu) project."""
+tags = ['Biological', 'Protein interactions', 'Unweighted']
+url = 'http://konect.cc/networks/maayan-Stelzl'
+citation = [('U. Stelzl et al. "A human protein-protein interaction network: a resource for annotating the proteome." Cell 122, 957-968 (2005)', 'http://www.sciencedirect.com/science/article/pii/S0092867405008664')]
+icon_hash = '58065a248cf714f319c3be90'
+upstream_prefix = 'http://konect.cc/files'
+files = [('download.tsv.maayan-Stelzl.tar.bz2', None, 'konect')]
+
+def fetch_upstream(force=False):
+    return fetch_upstream_files(__name__.split(".")[-1], upstream_prefix, files,
+                                force)
+
+@cache_network()
+@coerce_props()
+@annotate()
+def parse(alts=None):
+    global files
+    name = __name__.split(".")[-1]
+    for fnames, alt, fmt in files:
+        if alts is not None and alt not in alts:
+            continue
+        if isinstance(fnames, str):
+            fnames = [fnames]
+        with ExitStack() as stack:
+            fs = [stack.enter_context(open_upstream_file(name, fn, "rb")) for fn in fnames]
+            g = parse_graph(fs, fmt, directed=True)
+        yield alt, g