clinical_trials — Clinical trials and their conditions, interventions, sponsors, sites and investigators (ClinicalTrials.gov)

Description

The clinical studies registered in ClinicalTrials.gov, the registry of clinical research studies of the U.S. National Library of Medicine, which covers studies in the U.S. and in more than 200 other countries (about 610,000 studies in October 2026), with the conditions they study, the interventions they test, their sponsors and collaborators, the sites (facilities) where they take place, and their investigators. Each network is an undirected bipartite network of the studies and one kind of related entity:

• conditions: studies and the conditions (diseases) they study, as the Medical Subject Headings (MeSH) descriptors assigned to the conditions by ClinicalTrials.gov.
• interventions: studies and their interventions (drugs, devices, procedures, ...), as the MeSH descriptors assigned to the interventions by ClinicalTrials.gov.
• sponsors: studies and the organizations that sponsor them (the lead sponsor and the collaborators), identified by their names as given.
• sites: studies and their sites (facilities, e.g. hospitals), identified by their name, city, state and country as given.
• investigators: studies and their investigators, i.e. the persons responsible for the scientific conduct of the study as given by the registry ("overall officials": principal investigators, study directors and study chairs), identified by their name and affiliation exactly as given (not disambiguated: the same person with differently written names or affiliations appears as several nodes, and different persons of the same name and affiliation are merged).

The registry is updated daily, and its downloads are not versioned: the networks are of the download date (the data were checked on 31 October 2026). The contact persons of the studies (central and site contacts) and the investigators of the individual sites are left out, as are the free-text descriptions, the outcomes and the results of the studies. Studies whose conditions or interventions were not mapped to MeSH descriptors have no edges in those networks (their conditions and interventions as given are in the properties conditions and intervention_names).

The networks have the following properties:

• (Node) is_study: whether the node is a study.
• (Node) name: the NCT number of the study (its page is https://clinicaltrials.gov/study/<name>), the MeSH descriptor (e.g. Lung Neoplasms), the name of the organization, the name of the facility, or the name of the investigator (as given, often with degrees, e.g. Jane Doe, MD).
• (Node) title (studies): the brief title.
• (Node) study_type (studies): INTERVENTIONAL, OBSERVATIONAL, EXPANDED_ACCESS.
• (Node) phases (studies): the phases (e.g. PHASE2|PHASE3).
• (Node) status (studies): the overall recruitment status, e.g. COMPLETED, RECRUITING.
• (Node) start_date, completion_date and first_posted (studies): the dates of start, completion and first posting (Unix time, -1 if unknown; dates given as a month are taken as its first day).
• (Node) enrollment (studies): the number of participants, actual or anticipated; -1 if unknown.
• (Node) has_results (studies): whether the study has results.
• (Node) sponsor_class (studies): the class of the lead sponsor: INDUSTRY, NIH, FED, OTHER_GOV, NETWORK, OTHER, ...
• (Node) conditions (studies): the conditions as given, separated by |.
• (Node) intervention_names (studies): the interventions as given, as <type>: <name>, separated by |.
• (Node) mesh_id (MeSH descriptors, conditions, interventions): the MeSH identifier (e.g. D008175).
• (Node) org_class (organizations, sponsors): the class of the organization, as above.
• (Edge) role (sponsors): lead_sponsor or collaborator.
• (Node) city, state, zip, country (sites, sites): the address of the site.
• (Node) latitude, longitude (sites, sites): the coordinates of the site (NaN if unknown).
• (Edge) site_status (sites): the recruitment status of the site, if given.
• (Node) affiliation (investigators, investigators): the affiliation, as given.
• (Edge) role (investigators): the role of the investigator: PRINCIPAL_INVESTIGATOR, STUDY_DIRECTOR, STUDY_CHAIR (or empty if not given).

Tags

Biological Public Health Affiliation Bipartite Unweighted Metadata

Added

2026-10-31

Citation

• A. Tasneem, L. Aberle, H. Ananth, S. Chakraborty, K. Chiswell, B. J. McCourt, R. Pietrobon, "The Database for Aggregate Analysis of ClinicalTrials.gov (AACT) and Subsequent Regrouping by Clinical Specialty." PLoS ONE 7(3), e33677 (2012) 10.1371/journal.pone.0033677 Sci-Hub

Upstream URL OK

https://clinicaltrials.gov/
https://clinicaltrials.gov/data-api/api

Upstream license

ClinicalTrials.gov terms and conditions (U.S. government data, no copyright), https://clinicaltrials.gov/about-site/terms-conditions

Networks

Tip: click on a column header to sort the list, or hover over it for a description.

Column legend

$\left<k\right>$

Mean degree

$\sigma_k$

Standard deviation of the degrees

$\lambda_h$

Largest eigenvalue of the Hashimoto (non-backtracking) matrix

$\tau$

Random walk mixing time

$r$

Degree assortativity

$c$

Global clustering coefficient

$\oslash$

(Pseudo-) diameter

$S$

Relative size of the largest component

NPs

Node properties

EPs

Edge properties

Show all columns

Name	Nodes	Edges	$\left<k\right>$	$\sigma_k$	$\lambda_h$	$\tau$	$r$	$c$	$\oslash$	$S$	Kind	Mode	NPs	EPs	gt	GraphML	GML	csv
conditions	615,480	848,888	2.76	59.68	92.90	92.97	-0.25	0.00	15	0.79	Undirected	Bipartite	is_study name title study_type phases status start_date completion_date first_posted enrollment has_results sponsor_class conditions intervention_names mesh_id		29.1 MiB	43.0 MiB	41.6 MiB	55.8 MiB
interventions	624,273	476,921	1.53	23.69	70.22	201.43	-0.20	0.00	23	0.45	Undirected	Bipartite	is_study name title study_type phases status start_date completion_date first_posted enrollment has_results sponsor_class conditions intervention_names mesh_id		29.2 MiB	41.9 MiB	40.4 MiB	54.8 MiB
sponsors	712,866	971,186	2.72	35.67	48.17	1218.72	-0.10	0.00	25	0.90	Undirected	Bipartite	is_study name title study_type phases status start_date completion_date first_posted enrollment has_results sponsor_class conditions intervention_names org_class	role	32.6 MiB	47.1 MiB	45.6 MiB	59.5 MiB
sites	1,787,823	3,553,382	3.98	24.69	303.19	52748.11	-0.04	0.00	38	0.60	Undirected	Bipartite	is_study name title study_type phases status start_date completion_date first_posted enrollment has_results sponsor_class conditions intervention_names city state zip country latitude longitude	site_status	59.9 MiB	86.6 MiB	85.9 MiB	112.6 MiB
investigators	—	—	—	—	—	—	—	—	—	—					38.1 MiB	52.4 MiB	51.5 MiB	68.9 MiB