tumor_virus_host — Tumour virus-human protein interactions (2012)
- Description
A bipartite network of binary protein-protein interactions between proteins of DNA tumour viruses and human proteins, from Rozenblatt-Rosen et al. (2012), as distributed by the Center for Cancer Systems Biology (CCSB, Dana-Farber Cancer Institute). Open reading frames of viral proteins (from Epstein-Barr virus, adenovirus 5, polyomavirus SV40, and the human papillomaviruses HPV5, HPV6b, HPV8, HPV11, HPV16, HPV18 and HPV33) were screened by yeast two-hybrid (Y2H) assays against a library of human open reading frames (the human ORFeome). Nodes are viral and human proteins, and an undirected edge connects a viral protein to a human protein with which it interacts (454 interactions between 53 viral and 307 human proteins).
The network has the following properties:
is_viral: whether the node is a viral protein (otherwise it is a human protein).name: the name of the viral protein, as virus and protein (e.g. "EBV-EBNA1", "HPV16-E6"), or the gene symbol of the human protein.entrez_id: the Entrez Gene ID of the human protein (-1 for viral proteins).
- Tags
- Biological Protein interactions Unweighted Metadata
- Citation
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- O. Rozenblatt-Rosen, R. C. Deo, M. Padi, G. Adelmant, M. A. Calderwood, T. Rolland, et al., "Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins." Nature 487(7408), 491-495 (2012) 10.1038/nature11288 Sci-Hub
- Upstream URL OK
- https://web.archive.org/web/2017/http://interactome.dfci.harvard.edu/V_hostome/index.php?page=download
- Networks
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Tip: hover over a column header for a description.
Column legend
- $\left<k\right>$
- Mean degree
- $\sigma_k$
- Standard deviation of the degrees
- $\lambda_h$
- Largest eigenvalue of the Hashimoto (non-backtracking) matrix
- $\tau$
- Random walk mixing time
- $r$
- Degree assortativity
- $c$
- Global clustering coefficient
- $\oslash$
- (Pseudo-) diameter
- $S$
- Relative size of the largest component
- NPs
- Node properties
- EPs
- Edge properties