open_targets_associations — Open Targets target-disease associations (2021-2026)

Description

Bipartite networks of genes (drug targets) and diseases or phenotypes, from the Open Targets Platform, which integrates the evidence that a gene is involved in a disease from many sources (genetic associations, somatic mutations, known drugs, affected pathways, gene expression, animal models, and text mining of the literature) into association scores between 0 and 1, to help the selection of drug targets.

Nodes are targets (Ensembl genes) and diseases (terms of the Experimental Factor Ontology, EFO, and of the ontologies it imports, such as MONDO, HP, Orphanet and GO), and an edge connects a target and a disease that have an association, with its overall score, and its scores by type of evidence (data type).

2021 ... 2026: the direct associations (from evidence for the disease itself) of the releases of September of each year (21.09 to 26.09).
indirect_2026: the indirect associations of release 26.09, where the evidence for a disease is also propagated to all its ancestors in the ontology (only the overall score).

The scores by data source (finer than the data types), the yearly scores of release 26.09 (except the first year with a positive score), and the indirect associations of the earlier releases are left out.

The networks have the following properties:

(Node) is_target: whether the node is a target (otherwise it is a disease).
(Node) ot_id: the identifier of the target (Ensembl gene, e.g. ENSG00000141510) or disease (e.g. EFO_0000311, MONDO_0007254).
(Node) name: the approved symbol of the gene, or the name of the disease.
(Node) full_name (targets): the approved name of the gene.
(Node) biotype, chromosome (targets): the biotype of the gene (e.g. protein_coding) and its chromosome.
(Node) therapeutic_areas (diseases): the therapeutic areas of the disease (their identifiers).
(Edge) score: the overall association score.
(Edge) evidence_count: the number of pieces of evidence of the association.
(Edge) score_<datatype> (direct associations): the association score from the evidence of each data type (genetic_association, somatic_mutation, known_drug, affected_pathway, rna_expression, animal_model, literature, and the types of the release; NaN if there is no evidence of the type).
(Edge) novelty, first_year (2026, indirect_2026): the current novelty of the association (a measure of how recent its evidence is), and the first year in which its score was positive (-1 if unknown, e.g. for evidence without a date).

Tags

Biological Weighted Bipartite Metadata

Added

2026-10-31

Citation

A. Buniello, D. Suveges, C. Cruz-Castillo, M. B. Llinares, H. Cornu, I. Lopez, K. Tsukanov, J. M. Roldán-Romero, C. Mehta, L. Fumis, et al., "Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery." Nucleic Acids Research 53, D1467-D1475 (2025) 10.1093/nar/gkae1128 Sci-Hub

Upstream URL OK

https://platform.opentargets.org/
https://ftp.ebi.ac.uk/pub/databases/opentargets/platform/

Upstream license

Creative Commons CC0 1.0 Universal (CC0 1.0), https://creativecommons.org/publicdomain/zero/1.0/

Networks

Tip: click on a column header to sort the list, or hover over it for a description.

Column legend

$\left<k\right>$: Mean degree
$\sigma_k$: Standard deviation of the degrees
$\lambda_h$: Largest eigenvalue of the Hashimoto (non-backtracking) matrix
$\tau$: Random walk mixing time
$r$: Degree assortativity
$c$: Global clustering coefficient
$\oslash$: (Pseudo-) diameter
$S$: Relative size of the largest component
NPs: Node properties
EPs: Edge properties

Name	Nodes	Edges	$\left<k\right>$	$\sigma_k$	$\lambda_h$	$\tau$	$r$	$\oslash$	$S$	Kind	Mode	NPs	EPs	gt	GraphML	GML	csv
2021	43,344	2,174,364	100.33	300.78	596.80	2.37	-0.18	7	1.00	Undirected	Bipartite	is_target ot_id name full_name biotype chromosome therapeutic_areas	score evidence_count score_affected_pathway score_animal_model score_genetic_association score_known_drug score_literature score_rna_expression score_somatic_mutation	20.6 MiB	34.5 MiB	34.2 MiB	39.9 MiB
2022	44,230	2,153,389	97.37	296.61	590.25	4.94	-0.19	7	1.00	Undirected	Bipartite	is_target ot_id name full_name biotype chromosome therapeutic_areas	score evidence_count score_affected_pathway score_animal_model score_genetic_association score_known_drug score_literature score_rna_expression score_somatic_mutation	20.2 MiB	33.8 MiB	33.5 MiB	39.5 MiB
2023	45,461	2,505,099	110.21	353.79	691.12	2.89	-0.18	6	1.00	Undirected	Bipartite	is_target ot_id name full_name biotype chromosome therapeutic_areas	score evidence_count score_affected_pathway score_animal_model score_genetic_association score_known_drug score_literature score_rna_expression score_somatic_mutation	22.2 MiB	37.9 MiB	37.5 MiB	43.8 MiB
2024	48,016	2,725,301	113.52	349.57	709.94	2.89	-0.18	7	1.00	Undirected	Bipartite	is_target ot_id name full_name biotype chromosome therapeutic_areas	score evidence_count score_affected_pathway score_animal_model score_genetic_association score_known_drug score_literature score_rna_expression score_somatic_mutation	23.5 MiB	40.5 MiB	40.1 MiB	47.1 MiB
2025	53,971	3,987,332	147.76	455.37	957.68	3.99	-0.22	7	1.00	Undirected	Bipartite	is_target ot_id name full_name biotype chromosome therapeutic_areas	score evidence_count score_affected_pathway score_animal_model score_genetic_association score_known_drug score_literature score_rna_expression score_somatic_mutation	33.1 MiB	58.5 MiB	57.9 MiB	66.5 MiB
2026	57,799	7,225,847	250.03	585.65	1151.01	3.14	-0.21	6	1.00	Undirected	Bipartite	is_target ot_id name full_name biotype chromosome therapeutic_areas	score evidence_count novelty first_year score_affected_pathway score_animal_model score_genetic_association score_genetic_literature score_known_drug score_literature score_rna_expression score_somatic_mutation	91.2 MiB	141.8 MiB	138.6 MiB	177.0 MiB
indirect_2026	59,444	17,459,960	587.44	1363.96	2512.23	2.18	-0.33	6	1.00	Undirected	Bipartite	is_target ot_id name full_name biotype chromosome therapeutic_areas	score evidence_count novelty first_year	155.3 MiB	231.8 MiB	227.8 MiB	241.6 MiB